Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 1
1979 1
1980 4
1981 7
1982 12
1983 9
1984 11
1985 17
1986 18
1987 16
1988 16
1989 19
1990 21
1991 15
1992 20
1993 10
1994 12
1995 7
1996 10
1997 11
1998 6
1999 2
2000 7
2001 7
2002 4
2003 7
2004 6
2005 5
2006 3
2007 2
2008 3
2009 3
2010 7
2011 4
2012 2
2013 1
2014 3
2015 1
2016 3
2017 3
2018 2
2019 3
2020 1
2021 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

318 results

Results by year

Filters applied: . Clear all
Page 1
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight.
Tian S, Zhang D, Zhou W, Tan C, Shan Q, Ma R, Xing Z, Sui W, Zhang Z. Tian S, et al. Pain Med. 2021 Jun 4;22(6):1246-1252. doi: 10.1093/pm/pnaa316. Pain Med. 2021. PMID: 33094312 Clinical Trial.
OBJECTIVE: To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection pain. ...MEASUREMENTS: The ED50 and 95% …
OBJECTIVE: To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of pr …
Minimum effective dose of spinal ropivacaine with and without fentanyl for postpartum tubal ligation.
Panni MK, George RB, Allen TK, Olufolabi AJ, Schultz JR, Okumura M, Columb MO, Habib AS. Panni MK, et al. Int J Obstet Anesth. 2010 Oct;19(4):390-4. doi: 10.1016/j.ijoa.2010.06.011. Epub 2010 Sep 15. Int J Obstet Anesth. 2010. PMID: 20832280
RESULTS: The first and second studies recruited 24 and 17 patients, respectively. The median effective dose (ED50) for hyperbaric spinal ropivacaine was 16.4 mg (95% CI 13.7-19) with an ED95 estimate of 21.9 mg. The median effective dose of spin …
RESULTS: The first and second studies recruited 24 and 17 patients, respectively. The median effective dose (ED50) for …
The Effectiveness and Stability of a 20% Emulsified Sevoflurane Formulation for Intravenous Use in Rats.
Morohashi T, Itakura S, Shimokawa KI, Ishii F, Ikeda T, Kazama T. Morohashi T, et al. Anesth Analg. 2016 Mar;122(3):712-718. doi: 10.1213/ANE.0000000000001070. Anesth Analg. 2016. PMID: 26716717
METHODS: We prepared a 20% sevoflurane lipid emulsion and administered it to 69 male Sprague-Dawley rats via the tail vein. The median effective dose (ED50) for the loss of righting reflex and the median lethal dose (LD50) were determined. ...CONCLUSIO …
METHODS: We prepared a 20% sevoflurane lipid emulsion and administered it to 69 male Sprague-Dawley rats via the tail vein. The median ef …
Preliminary safety assessment of oridonin in zebrafish.
Tian L, Sheng D, Li Q, Guo C, Zhu G. Tian L, et al. Pharm Biol. 2019 Dec;57(1):632-640. doi: 10.1080/13880209.2019.1662457. Pharm Biol. 2019. PMID: 31545911 Free PMC article.
Results: Low-dose oridonin increased spontaneous movement and hatching rate with median effective doses (ED(50)) of 115.17 mg/L at 24 h post-fertilization (hpf) and 188.59 mg/L at 54 hpf, but these values decreased at high doses with half maximal inhibitory concentr …
Results: Low-dose oridonin increased spontaneous movement and hatching rate with median effective doses (ED(50)) of 115.17 mg/ …
Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine.
Yudin MA, Vengerovich NG, Sagalov GS, Vahvijanen MS, Bykov VN, Chepur SV. Yudin MA, et al. Bull Exp Biol Med. 2016 Dec;162(2):215-219. doi: 10.1007/s10517-016-3579-8. Epub 2016 Dec 2. Bull Exp Biol Med. 2016. PMID: 27913936
The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. A …
The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5 …
Modulation of anxiety by beta-carbolines and other benzodiazepine receptor ligands: relationship of pharmacological to biochemical measures of efficacy.
Stephens DN, Schneider HH, Kehr W, Jensen LH, Petersen E, Honore T. Stephens DN, et al. Brain Res Bull. 1987 Sep;19(3):309-18. doi: 10.1016/0361-9230(87)90099-2. Brain Res Bull. 1987. PMID: 2824003 Review.
They included two beta-carbolines, ZK 91 296 and ZK 95 962, and the pyrazoloquinoline CGS 9896, and these 3 substances were also distinguishable in not producing rate-decreasing effects in any of the 3 operant tests. The second group were anxiogenic in that they produced a …
They included two beta-carbolines, ZK 91 296 and ZK 95 962, and the pyrazoloquinoline CGS 9896, and these 3 substances were also distinguish …
Vasoactivity of trimetazidine on guinea-pig isolated ductus arteriosus.
Garnier D, Roulet MJ. Garnier D, et al. Br J Pharmacol. 1985 Feb;84(2):517-24. doi: 10.1111/j.1476-5381.1985.tb12936.x. Br J Pharmacol. 1985. PMID: 3978320 Free PMC article.
When the PO2 of the bathing solution was 75 mmHg, TMZ caused a dose-dependent increase in tension. The median effective dose (ED50) for the drug was 8 X 10(-5)M. ...At the maximally effective dose of 10(-3)M, and during low PO2, the TMZ-i …
When the PO2 of the bathing solution was 75 mmHg, TMZ caused a dose-dependent increase in tension. The median effective dos …
Role of glucose in contractility of airway smooth muscle.
Souhrada JF, Loader J. Souhrada JF, et al. Respir Physiol. 1979 Feb;36(2):231-47. doi: 10.1016/0034-5687(79)90027-6. Respir Physiol. 1979. PMID: 441576
The reactivity of ITP was measured by ED50 (effective dose developing 50% of maximal response); and the contractility of ITP was measured by a maximal developed isometric tension. ...In both experiments, either with or without glucose in the experimental m …
The reactivity of ITP was measured by ED50 (effective dose developing 50% of maximal response); and the contractility o …
Effect of structural modification of the hydantoin ring on anticonvulsant activity.
Cortes S, Liao ZK, Watson D, Kohn H. Cortes S, et al. J Med Chem. 1985 May;28(5):601-6. doi: 10.1021/jm50001a012. J Med Chem. 1985. PMID: 3989820
Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples), 2-imidazolones 3 (10 examples), 2-imidazolidinones 4 (four examples), vicinal diamines 5 (two examples), and simple amino acid derivatives 6 (four examples) have been prepared and ev …
Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples), 2-imidazolones 3 (10 examples), 2-imidazol …
The Role of Prostaglandin E1 as a Pain Mediator through Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of Mice.
Kwon J, Choi YI, Jo HJ, Lee SH, Lee HK, Kim H, Moon JY, Jung SJ. Kwon J, et al. Int J Mol Sci. 2021 Dec 16;22(24):13534. doi: 10.3390/ijms222413534. Int J Mol Sci. 2021. PMID: 34948328 Free PMC article.
The HCN channel-generated inward current (I(h)) was increased by 135.3 4.8% at 100 nM of PGE1 in small- or medium-sized TG, and the action of PGE1 on I(h) showed a concentration-dependent effect, with a median effective dose (ED(50)) of 29.3 nM. ...
The HCN channel-generated inward current (I(h)) was increased by 135.3 4.8% at 100 nM of PGE1 in small- or medium-sized TG, and the a …
318 results